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Clozapine is a dibenzodiazepine that is structurally very similar to loxapine (originally deemed a typical antipsychotic). sharp sj 237 mg It is slightly soluble in water, soluble in acetone, and highly soluble in chloroform Its solubility in water is 0 1889 mg/L (25 °C) Its manufacturer, Novartis, claims a solubility of 0 01% in water (100 mg/L)